Washington University in St. Louis

New Publication for You Lab

Congratulations to Sharad Paudyal and Zhongsheng You on their new publication in Acta Biochim Biophys Sin (Shanghai).

Paudyal, SC, and You, Z.  (2016)  Sharpening the ends for repair: mechanisms and regulation of DNA resection.  Acta Biochim. Biophys Sinc (Shainghai) doi: 10.1093/abbs/gmw043 [E-published online May 12]

Abstract:  DNA end resection is a key process in the cellular response to DNA double-strand break damage that is essential for genome maintenance and cell survival. Resection involves selective processing of 5′ ends of broken DNA to generate ssDNA overhangs, which in turn control both DNA repair and checkpoint signaling. DNA resection is the first step in homologous recombination-mediated repair and a prerequisite for the activation of the ataxia telangiectasia mutated and Rad3-related (ATR)-dependent checkpoint that coordinates repair with cell cycle progression and other cellular processes. Resection occurs in a cell cycle-dependent manner and is regulated by multiple factors to ensure an optimal amount of ssDNA required for proper repair and genome stability. Here, we review the latest findings on the molecular mechanisms and regulation of the DNA end resection process and their implications for cancer formation and treatment.

To access the complete journal article, click here.

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