New Review Article for Huettner in the Journal of Physiology
Jim Huettner's invited review article titled Glutamate Receptor Pores is available on the Journal of Physiology 's website under "Latest Articles".
Huettner, J.E. (2014) Glutamate Receptor Pores. J Physiol [E-published ahead of print April 7]
Abstract: Glutamate receptors are ligand-gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo or heteromeric tetramers with each subunit contributing a re-entrant pore loop that dips into the membrane from the cytoplasmic side. The pore loops form a narrow constriction near their apex with a wide vestibule toward the cytoplasm and an aqueous central cavity facing the extracellular solution. This article focuses on the pore region reviewing how structural differences among glutamate receptor subtypes determine their distinct functional properties.
To access this article, click here.